[HTML][HTML] RNA-Binding Macrocyclic Peptides

S Pal, P 't Hart - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
… of cyclic peptides that target more complex tertiary folds of … Structural studies of this new
RRM in complex with the TARstructure of the peptide:RNA complex further revealed that the …

[图书][B] Use of Lab-Evolved Proteins to Guide Development of Inhibitors that Target HIV-1 TAR RNA

SS Chavali - 2021 - search.proquest.com
… -Tat interaction represents a viable target for functional cure therapy. Numerous studies have
determined the structures of HIV TAR in complex with BIV-Tat … strong peptideRNA binding …

Correlation in Domain Fluctuations Navigates Target Search of a Viral Peptide along RNA

S Prusty, R Sarkar, A Chakraborty… - The Journal of Physical …, 2021 - ACS Publications
… peptide along with the solution NMR structure of the BIV TARTat complex is shown in …
of the TAR RNA to generate the initial structure of the BIV TARTat complex for simulations. …

[HTML][HTML] Binding of hnRNP I–vRNA Regulates Sindbis Virus Structural Protein Expression to Promote Particle Infectivity

CE Westcott, S Qazi, AM Maiocco, S Mukhopadhyay… - Viruses, 2022 - mdpi.com
… The primary goal of this study was to determine whether the … RNA complexes in lysates
generated from HEK293 cells that … the native interaction site via the BIV-TAR/TAT system, we next …

Genetically encoded RNA-based bioluminescence resonance energy transfer (BRET) sensors

L Mi, Q Yu, APKK Karunanayake Mudiyanselage… - ACS …, 2023 - ACS Publications
… In this project, our goal is to design a novel type of … wondered if natural RNA–protein
complexes can also be used to … Our results indicated that the fusion of Pepper and TAR via these …

[PDF][PDF] Development of fluorogenic peptide probes carrying internally-incorporated cyanine dyes as FID indicators for dsRNAs

ETT Lee - tohoku.repo.nii.ac.jp
… small molecules that can specifically bind to RNA structural features … RNP complex– the
HIV-1 Tat protein – HIV-1 TAR RNA … with the drug target, as such, we have decided that a good …

Crosslinked Helical Fork: Towards a Rationally Designed Encodable Scaffold for the Sequence-Specific Targeting of Double-Stranded RNA

JG Kwok - 2023 - search.proquest.com
… effort towards developing a scaffold that targets the stem duplex by … complexes, Rnt1p–siRNA20
and EIAV TatTAR,21 that have … While the native peptide-RNA complex features several …

Investigating chemical crosslinking of protein-RNA complexes by mass spectrometry

A Wulf - 2022 - ediss.uni-goettingen.de
… low-abundant crosslinked peptide-RNA moieties entering the mass … Crosslinking sites from
the NELF complex bound to TAR-… N-hydroxysuccinimide esters that specifically target primary …

[PDF][PDF] Combating an intrinsic antibiotic resistance mechanism by interfering with small RNA regulation of an outer membrane porin

A Batresian - 2021 - scholarworks.calstate.edu
TAR RNA complexes shows how two RNAs that are similar … The first goal of this study laid
the way for the subsequent goals … design rules for peptide-RNA interactions can be developed. …

Different views of the dynamic landscape covered by the 5'-hairpin of the 7SK small nuclear RNA

K Brillet, D Martinez-Zapien, G Bec, E Ennifar… - RNA, 2020 - rnajournal.cshlp.org
… in the formation of the complexes. The present manuscript thus … the buffer composition (pH
and Mg 2+ ) on the structure and … showing that Tat-ARM and HEXIM1-ARM peptides target